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2hvx
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2hvx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HVX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HVX FirstGlance]. <br> | <table><tr><td colspan='2'>[[2hvx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HVX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HVX FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DRX:[(1S)-1-(5-CHLORO-1-BENZOTHIEN-3-YL)-2-(2-NAPHTHYLAMINO)-2-OXOETHYL]PHOSPHONIC+ACID'>DRX</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DRX:[(1S)-1-(5-CHLORO-1-BENZOTHIEN-3-YL)-2-(2-NAPHTHYLAMINO)-2-OXOETHYL]PHOSPHONIC+ACID'>DRX</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chymase Chymase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.39 3.4.21.39] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chymase Chymase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.39 3.4.21.39] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hvx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hvx RCSB], [http://www.ebi.ac.uk/pdbsum/2hvx PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hvx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hvx RCSB], [http://www.ebi.ac.uk/pdbsum/2hvx PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Almond, H R]] | [[Category: Almond, H R]] | ||
| - | [[Category: Cantwell, A M | + | [[Category: Cantwell, A M]] |
| - | [[Category: Cera, E Di | + | [[Category: Cera, E Di]] |
| - | [[Category: Damiano, B P | + | [[Category: Damiano, B P]] |
| - | [[Category: Garavilla, L de | + | [[Category: Garavilla, L de]] |
| - | [[Category: Greco, M N | + | [[Category: Greco, M N]] |
| - | [[Category: Hawkins, M J | + | [[Category: Hawkins, M J]] |
| - | [[Category: Maryanoff, B E | + | [[Category: Maryanoff, B E]] |
| - | [[Category: Minor, L A | + | [[Category: Minor, L A]] |
| - | [[Category: Powell, E T | + | [[Category: Powell, E T]] |
| - | [[Category: Savvides, S N | + | [[Category: Savvides, S N]] |
| - | [[Category: Wang, Y | + | [[Category: Wang, Y]] |
| - | [[Category: Wells, G I | + | [[Category: Wells, G I]] |
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Serine protease]] | [[Category: Serine protease]] | ||
Revision as of 08:36, 16 January 2015
Discovery of Potent, Orally Active, Nonpeptide Inhibitors of Human Mast Cell Chymase by Using Structure-Based Drug Design
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