2j6w

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2j6w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J6W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J6W FirstGlance]. <br>
<table><tr><td colspan='2'>[[2j6w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J6W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J6W FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ean|1ean]], [[1eao|1eao]], [[1eaq|1eaq]], [[1hjb|1hjb]], [[1hjc|1hjc]], [[1io4|1io4]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ean|1ean]], [[1eao|1eao]], [[1eaq|1eaq]], [[1hjb|1hjb]], [[1hjc|1hjc]], [[1io4|1io4]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j6w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j6w RCSB], [http://www.ebi.ac.uk/pdbsum/2j6w PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j6w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j6w RCSB], [http://www.ebi.ac.uk/pdbsum/2j6w PDBsum]</span></td></tr>
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<table>
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</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/RUNX1_MOUSE RUNX1_MOUSE]] Note=Mice with an Runx1 lacking the DNA-binding region are found to die between embryonic days 11.5 to 12.5 due to hemorrhaging in the central nervous system. This hemorrhaging is preceded by necrosis and hematopoiesis is blocked.
[[http://www.uniprot.org/uniprot/RUNX1_MOUSE RUNX1_MOUSE]] Note=Mice with an Runx1 lacking the DNA-binding region are found to die between embryonic days 11.5 to 12.5 due to hemorrhaging in the central nervous system. This hemorrhaging is preceded by necrosis and hematopoiesis is blocked.
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</StructureSection>
</StructureSection>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Bielnicka, I.]]
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[[Category: Bielnicka, I]]
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[[Category: Bushweller, J H.]]
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[[Category: Bushweller, J H]]
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[[Category: Grembecka, J.]]
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[[Category: Grembecka, J]]
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[[Category: Liu, Y.]]
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[[Category: Liu, Y]]
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[[Category: Lukasik, S M.]]
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[[Category: Lukasik, S M]]
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[[Category: Speck, N A.]]
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[[Category: Speck, N A]]
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[[Category: Zhe, L.]]
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[[Category: Zhe, L]]
[[Category: Acute myeloid leukemia]]
[[Category: Acute myeloid leukemia]]
[[Category: Aml]]
[[Category: Aml]]

Revision as of 18:34, 19 January 2015

R164N MUTANT OF THE RUNX1 RUNT DOMAIN

2j6w, resolution 2.60Å

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