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2p2k
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2p2k]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P2K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P2K FirstGlance]. <br> | <table><tr><td colspan='2'>[[2p2k]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P2K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P2K FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ovu|2ovu]], [[2ow4|2ow4]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ovu|2ovu]], [[2ow4|2ow4]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p2k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p2k RCSB], [http://www.ebi.ac.uk/pdbsum/2p2k PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p2k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p2k RCSB], [http://www.ebi.ac.uk/pdbsum/2p2k PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CONA_CANGL CONA_CANGL]] Glucose/D-mannose/rhamnose specific lectin. Has hemagglutinating activity towards rabbit erythrocytes. Has mitogenic activity towards murine splenocytes that is inhibited by glucose. Inhibits HIV-1 reverse transcriptase with an IC(50) of 35uM. Has a potent antiproliferative activity against L1210 leukemia cells in vitro that is not inhibited by glucose. Inhibits translation in cell-free rabbit reticulocyte system with an IC(50) of 2.08uM. Lacks anti-fungal activity against M.arachidicola, B.cenera and F.oxysporum.<ref>PMID:15935326</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Canavalia gladiata]] | [[Category: Canavalia gladiata]] | ||
| - | [[Category: Azevedo, W F.de | + | [[Category: Azevedo, W F.de]] |
| - | [[Category: Benevides, G B | + | [[Category: Benevides, G B]] |
| - | [[Category: Bezerra, G A | + | [[Category: Bezerra, G A]] |
| - | [[Category: Cavada, B S | + | [[Category: Cavada, B S]] |
| - | [[Category: Delatorre, P | + | [[Category: Delatorre, P]] |
| - | [[Category: Moreno, F B.M B | + | [[Category: Moreno, F B.M B]] |
| - | [[Category: Oliveira, T M | + | [[Category: Oliveira, T M]] |
| - | [[Category: Rocha, B A.M | + | [[Category: Rocha, B A.M]] |
| - | [[Category: Souza, E P | + | [[Category: Souza, E P]] |
[[Category: Canavalia gladiata lectin]] | [[Category: Canavalia gladiata lectin]] | ||
[[Category: Dimannoside]] | [[Category: Dimannoside]] | ||
[[Category: Man1-4man-ome]] | [[Category: Man1-4man-ome]] | ||
[[Category: Sugar binding protein]] | [[Category: Sugar binding protein]] | ||
Revision as of 17:35, 24 December 2014
Crystal structure of a lectin from Canavalia gladiata seeds (CGL) in complex with man1-4man-OMe
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