1ib2
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1ib3|1IB3]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ib2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ib2 OCA], [http://www.ebi.ac.uk/pdbsum/1ib2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ib2 RCSB]</span> | ||
}} | }} | ||
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[[Category: Wang, X.]] | [[Category: Wang, X.]] | ||
[[Category: Zamore, P D.]] | [[Category: Zamore, P D.]] | ||
| - | + | [[Category: pumilio-homology domain,puf motif]] | |
| - | + | ||
| - | [[Category: pumilio-homology domain]] | + | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:17:15 2008'' |
Revision as of 18:17, 30 March 2008
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| , resolution 1.90Å | |||||||
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| Ligands: | |||||||
| Related: | 1IB3
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF A PUMILIO-HOMOLOGY DOMAIN
Overview
Puf proteins regulate translation and mRNA stability by binding sequences in their target RNAs through the Pumilio homology domain (PUM-HD), which is characterized by eight tandem copies of a 36 amino acid motif, the PUM repeat. We have solved the structure of the PUM-HD from human Pumilio1 at 1.9 A resolution. The structure reveals that the eight PUM repeats correspond to eight copies of a single, repeated structural motif. The PUM repeats pack together to form a right-handed superhelix that approximates a half doughnut. The distribution of side chains on the inner and outer faces of this half doughnut suggests that the inner face of the PUM-HD binds RNA while the outer face interacts with proteins such as Nanos, Brain Tumor, and cytoplasmic polyadenylation element binding protein.
About this Structure
1IB2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of a Pumilio homology domain., Wang X, Zamore PD, Hall TM, Mol Cell. 2001 Apr;7(4):855-65. PMID:11336708
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