2px9

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2px9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PX9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PX9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2px9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PX9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PX9 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2px9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2px9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2px9 RCSB], [http://www.ebi.ac.uk/pdbsum/2px9 PDBsum]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2px9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2px9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2px9 RCSB], [http://www.ebi.ac.uk/pdbsum/2px9 PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/SAE2_HUMAN SAE2_HUMAN]] The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.<ref>PMID:11481243</ref> <ref>PMID:11451954</ref> <ref>PMID:19443651</ref> <ref>PMID:15660128</ref> <ref>PMID:17643372</ref> <ref>PMID:20164921</ref> [[http://www.uniprot.org/uniprot/UBC9_HUMAN UBC9_HUMAN]] Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation.<ref>PMID:8668529</ref> <ref>PMID:11451954</ref> <ref>PMID:15809060</ref> <ref>PMID:19744555</ref> <ref>PMID:19638400</ref> <ref>PMID:17466333</ref> <ref>PMID:20077568</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Cai, S.]]
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[[Category: Cai, S]]
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[[Category: Chen, Y.]]
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[[Category: Chen, Y]]
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[[Category: Hu, W D.]]
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[[Category: Hu, W D]]
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[[Category: Lee, B.]]
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[[Category: Lee, B]]
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[[Category: Song, J.]]
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[[Category: Song, J]]
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[[Category: Wang, J H.]]
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[[Category: Wang, J H]]
[[Category: E1]]
[[Category: E1]]
[[Category: E2]]
[[Category: E2]]

Revision as of 17:46, 25 December 2014

The intrinsic affinity between E2 and the Cys domain of E1 in Ubiquitin-like modifications

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