2pkd
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2pkd]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PKD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PKD FirstGlance]. <br> | <table><tr><td colspan='2'>[[2pkd]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PKD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PKD FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD84, SLAMF5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD84, SLAMF5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pkd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pkd RCSB], [http://www.ebi.ac.uk/pdbsum/2pkd PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pkd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pkd RCSB], [http://www.ebi.ac.uk/pdbsum/2pkd PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SLAF5_HUMAN SLAF5_HUMAN]] Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain-containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells.<ref>PMID:11564780</ref> <ref>PMID:12115647</ref> <ref>PMID:12928397</ref> <ref>PMID:12962726</ref> <ref>PMID:16037392</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Almo, S C | + | [[Category: Almo, S C]] |
| - | [[Category: Cao, E | + | [[Category: Cao, E]] |
| - | [[Category: Cole, J L | + | [[Category: Cole, J L]] |
| - | [[Category: Fedorov, A | + | [[Category: Fedorov, A]] |
| - | [[Category: Lary, J W | + | [[Category: Lary, J W]] |
| - | [[Category: Malashkevich, V N | + | [[Category: Malashkevich, V N]] |
| - | [[Category: Nathenson, S G | + | [[Category: Nathenson, S G]] |
| - | [[Category: Yan, Q | + | [[Category: Yan, Q]] |
[[Category: Igc]] | [[Category: Igc]] | ||
[[Category: Igv]] | [[Category: Igv]] | ||
Revision as of 07:58, 24 December 2014
Crystal structure of CD84: Insite into SLAM family function
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