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2p0h
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2p0h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P0H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P0H FirstGlance]. <br> | <table><tr><td colspan='2'>[[2p0h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P0H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P0H FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I3S:(1S,3S,4S)-1,3,4-TRIPHOSPHO-MYO-INOSITOL'>I3S</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I3S:(1S,3S,4S)-1,3,4-TRIPHOSPHO-MYO-INOSITOL'>I3S</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2p0d|2p0d]], [[2p0f|2p0f]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2p0d|2p0d]], [[2p0f|2p0f]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ARHGAP9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ARHGAP9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p0h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p0h RCSB], [http://www.ebi.ac.uk/pdbsum/2p0h PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p0h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p0h RCSB], [http://www.ebi.ac.uk/pdbsum/2p0h PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RHG09_HUMAN RHG09_HUMAN]] GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix.<ref>PMID:11396949</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Blasutig, I | + | [[Category: Blasutig, I]] |
| - | [[Category: Ceccarelli, D F.J | + | [[Category: Ceccarelli, D F.J]] |
| - | [[Category: Goudreault, M | + | [[Category: Goudreault, M]] |
| - | [[Category: Pawson, T | + | [[Category: Pawson, T]] |
| - | [[Category: Ruston, J | + | [[Category: Ruston, J]] |
| - | [[Category: Sicheri, F | + | [[Category: Sicheri, F]] |
[[Category: Ligand binding protein]] | [[Category: Ligand binding protein]] | ||
[[Category: Pleckstrin homology domain]] | [[Category: Pleckstrin homology domain]] | ||
[[Category: Protein-phosphoinositide complex]] | [[Category: Protein-phosphoinositide complex]] | ||
Revision as of 23:04, 24 December 2014
ArhGAP9 PH domain in complex with Ins(1,3,4)P3
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