2qxg
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2qxg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QXG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QXG FirstGlance]. <br> | <table><tr><td colspan='2'>[[2qxg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QXG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QXG FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K7I:L-ALANYL-N-[(1S,2R)-1-BENZYL-2-HYDROXYPROPYL]-L-ALANINAMIDE'>K7I</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K7I:L-ALANYL-N-[(1S,2R)-1-BENZYL-2-HYDROXYPROPYL]-L-ALANINAMIDE'>K7I</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2qxh|2qxh]], [[2qxi|2qxi]], [[2qxj|2qxj]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2qxh|2qxh]], [[2qxi|2qxi]], [[2qxj|2qxj]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KLK7, PRSS6, SCCE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KLK7, PRSS6, SCCE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Stratum_corneum_chymotryptic_enzyme Stratum corneum chymotryptic enzyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.117 3.4.21.117] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Stratum_corneum_chymotryptic_enzyme Stratum corneum chymotryptic enzyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.117 3.4.21.117] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qxg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qxg RCSB], [http://www.ebi.ac.uk/pdbsum/2qxg PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qxg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qxg RCSB], [http://www.ebi.ac.uk/pdbsum/2qxg PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KLK7_HUMAN KLK7_HUMAN]] May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 33: | Line 35: | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Stratum corneum chymotryptic enzyme]] | [[Category: Stratum corneum chymotryptic enzyme]] | ||
| - | [[Category: Bode, W | + | [[Category: Bode, W]] |
| - | [[Category: Debela, M | + | [[Category: Debela, M]] |
| - | [[Category: Goettig, P | + | [[Category: Goettig, P]] |
| - | [[Category: Hess, P | + | [[Category: Hess, P]] |
| - | [[Category: Magdolen, V | + | [[Category: Magdolen, V]] |
| - | [[Category: Steiner, T | + | [[Category: Steiner, T]] |
[[Category: 37 loop]] | [[Category: 37 loop]] | ||
[[Category: Active site inhibitor]] | [[Category: Active site inhibitor]] | ||
Revision as of 17:56, 25 December 2014
Crystal Structure of Human Kallikrein 7 in Complex with Ala-Ala-Phe-chloromethylketone
| |||||||||||
