1ico
From Proteopedia
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|PDB= 1ico |SIZE=350|CAPTION= <scene name='initialview01'>1ico</scene> | |PDB= 1ico |SIZE=350|CAPTION= <scene name='initialview01'>1ico</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DPR:D-PROLINE'>DPR</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1icl|1ICL]], [[1ic9|1IC9]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ico FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ico OCA], [http://www.ebi.ac.uk/pdbsum/1ico PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ico RCSB]</span> | ||
}} | }} | ||
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[[Category: de novo protein design three-stranded beta-sheet mini-protein motif th motif]] | [[Category: de novo protein design three-stranded beta-sheet mini-protein motif th motif]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:17:55 2008'' |
Revision as of 18:17, 30 March 2008
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| Ligands: | , | ||||||
| Related: | 1ICL, 1IC9
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
SOLUTION STRUCTURE OF DESIGNED BETA-SHEET MINI-PROTEIN TH10BOX
Overview
Here we report the creation of a predominantly beta-structured mini-protein motif. The design target is based on the naturally occurring toxin hand (TH) motifs that are composed of four disulfide bonds and three loops that form a 'hand'. Analysis and subsequent modification of several generations of mini-proteins produced the final 29-residue mini-protein. The structured motif of this new mini-protein provides insight into the compensatory changes that result in the formation of a tightly packed hydrophobic core in a small, globular beta-structure motif. Additionally, this mini-motif represents a new, distinct surface topology for protein design and a valuable, yet compact, model system for the study of beta-sheet structure in water.
About this Structure
1ICO is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Design of a discretely folded mini-protein motif with predominantly beta-structure., Ottesen JJ, Imperiali B, Nat Struct Biol. 2001 Jun;8(6):535-9. PMID:11373623
Page seeded by OCA on Sun Mar 30 21:17:55 2008
