2wfl
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2wfl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rauvolfia_serpentina Rauvolfia serpentina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WFL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WFL FirstGlance]. <br> | <table><tr><td colspan='2'>[[2wfl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rauvolfia_serpentina Rauvolfia serpentina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WFL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WFL FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr> | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wfm|2wfm]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wfm|2wfm]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polyneuridine-aldehyde_esterase Polyneuridine-aldehyde esterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.78 3.1.1.78] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polyneuridine-aldehyde_esterase Polyneuridine-aldehyde esterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.78 3.1.1.78] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wfl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wfl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wfl RCSB], [http://www.ebi.ac.uk/pdbsum/2wfl PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wfl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wfl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wfl RCSB], [http://www.ebi.ac.uk/pdbsum/2wfl PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PNAE_RAUSE PNAE_RAUSE]] Catalyzes the hydrolysis of polyneuridine aldehyde into epi-vellosimine, which is the immediate precursor for the synthesis of the ajmaline.<ref>PMID:10691977</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Polyneuridine-aldehyde esterase]] | [[Category: Polyneuridine-aldehyde esterase]] | ||
[[Category: Rauvolfia serpentina]] | [[Category: Rauvolfia serpentina]] | ||
| - | [[Category: Hill, M | + | [[Category: Hill, M]] |
| - | [[Category: Panjikar, S | + | [[Category: Panjikar, S]] |
| - | [[Category: Stoeckigt, J | + | [[Category: Stoeckigt, J]] |
| - | [[Category: Wang, M | + | [[Category: Wang, M]] |
| - | [[Category: Yang, L | + | [[Category: Yang, L]] |
[[Category: Alkaloid metabolism]] | [[Category: Alkaloid metabolism]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
Revision as of 17:07, 25 December 2014
CRYSTAL STRUCTURE OF POLYNEURIDINE ALDEHYDE ESTERASE
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