2vqp
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2vqp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_respiratory_syncytial_virus Human respiratory syncytial virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VQP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VQP FirstGlance]. <br> | <table><tr><td colspan='2'>[[2vqp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_respiratory_syncytial_virus Human respiratory syncytial virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VQP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VQP FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vqp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vqp RCSB], [http://www.ebi.ac.uk/pdbsum/2vqp PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vqp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vqp RCSB], [http://www.ebi.ac.uk/pdbsum/2vqp PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MATRX_HRSVA MATRX_HRSVA]] Has a crucial role in virus assembly and budding. The matrix interacts with the RNP complex and this association serves two functions: facilitate virion assembly and inhibit the viral transcriptase activity. Early in infection, M is localized to the nucleus and may inhibit host cell transcription. Later on, M can associate with lipid rafts supposely by interacting with the cytoskeleton and with the cytoplasmic tail of glycoprotein G. The binding of M to host membrane is stabilized by the surface expression of the viral glycoproteins. These interactions may allow virus formation by mediating association of the nucleocapsid with the nascent envelop.<ref>PMID:11907323</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human respiratory syncytial virus]] | [[Category: Human respiratory syncytial virus]] | ||
| - | [[Category: Mcphee, H K | + | [[Category: Mcphee, H K]] |
| - | [[Category: Money, V A | + | [[Category: Money, V A]] |
| - | [[Category: Sanderson, J M | + | [[Category: Sanderson, J M]] |
| - | [[Category: Yeo, R P | + | [[Category: Yeo, R P]] |
[[Category: Envelope protein]] | [[Category: Envelope protein]] | ||
[[Category: Matrix protein]] | [[Category: Matrix protein]] | ||
Revision as of 23:24, 24 December 2014
STRUCTURE OF THE MATRIX PROTEIN FROM HUMAN RESPIRATORY SYNCYTIAL VIRUS
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