2wx0
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2wx0]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WX0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WX0 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2wx0]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WX0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WX0 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2c7m|2c7m]], [[1yd8|1yd8]], [[1e0q|1e0q]], [[2c7n|2c7n]], [[2fif|2fif]], [[2d3g|2d3g]], [[1v80|1v80]], [[1p3q|1p3q]], [[1wr6|1wr6]], [[2fid|2fid]], [[1v81|1v81]], [[1aar|1aar]], [[1uzx|1uzx]], [[1wrd|1wrd]], [[2wx1|2wx1]], [[2wwz|2wwz]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2c7m|2c7m]], [[1yd8|1yd8]], [[1e0q|1e0q]], [[2c7n|2c7n]], [[2fif|2fif]], [[2d3g|2d3g]], [[1v80|1v80]], [[1p3q|1p3q]], [[1wr6|1wr6]], [[2fid|2fid]], [[1v81|1v81]], [[1aar|1aar]], [[1uzx|1uzx]], [[1wrd|1wrd]], [[2wx1|2wx1]], [[2wwz|2wwz]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wx0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wx0 RCSB], [http://www.ebi.ac.uk/pdbsum/2wx0 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wx0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wx0 RCSB], [http://www.ebi.ac.uk/pdbsum/2wx0 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/TAB2_HUMAN TAB2_HUMAN]] Defects in TAB2 are the cause of congenital heart disease non-syndromic type 2 (CHTD2) [MIM:[http://omim.org/entry/612863 612863]]. It is a disease characterized by congenital developmental abnormalities involving structures of the heart. Clinical features include left ventricular outflow tract obstruction, subaortic stenosis, residual aortic regurgitation, atrial fibrillation, bicuspid aortic valve and aortic dilation. Note=A chromosomal aberration involving TAB2 has been found in a family with congenital heart disease. Translocation t(2;6)(q21;q25).<ref>PMID:20493459</ref> | [[http://www.uniprot.org/uniprot/TAB2_HUMAN TAB2_HUMAN]] Defects in TAB2 are the cause of congenital heart disease non-syndromic type 2 (CHTD2) [MIM:[http://omim.org/entry/612863 612863]]. It is a disease characterized by congenital developmental abnormalities involving structures of the heart. Clinical features include left ventricular outflow tract obstruction, subaortic stenosis, residual aortic regurgitation, atrial fibrillation, bicuspid aortic valve and aortic dilation. Note=A chromosomal aberration involving TAB2 has been found in a family with congenital heart disease. Translocation t(2;6)(q21;q25).<ref>PMID:20493459</ref> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Akutsu, M | + | [[Category: Akutsu, M]] |
| - | [[Category: Bremm, A | + | [[Category: Bremm, A]] |
| - | [[Category: Hofmann, K | + | [[Category: Hofmann, K]] |
| - | [[Category: Komander, D | + | [[Category: Komander, D]] |
| - | [[Category: Kulathu, Y | + | [[Category: Kulathu, Y]] |
[[Category: Isopeptide bond]] | [[Category: Isopeptide bond]] | ||
[[Category: Metal-binding]] | [[Category: Metal-binding]] | ||
Revision as of 10:30, 20 January 2015
TAB2 NZF DOMAIN IN COMPLEX WITH LYS63-LINKED DI-UBIQUITIN, P21
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