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2uyz

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2uyz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UYZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UYZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[2uyz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UYZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UYZ FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1u9a|1u9a]], [[1u9b|1u9b]], [[1a5r|1a5r]], [[1tgz|1tgz]], [[1wyw|1wyw]], [[1y8r|1y8r]], [[1z5s|1z5s]], [[2asq|2asq]], [[2bf8|2bf8]], [[2g4d|2g4d]], [[2io2|2io2]], [[2iy0|2iy0]], [[2iy1|2iy1]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1u9a|1u9a]], [[1u9b|1u9b]], [[1a5r|1a5r]], [[1tgz|1tgz]], [[1wyw|1wyw]], [[1y8r|1y8r]], [[1z5s|1z5s]], [[2asq|2asq]], [[2bf8|2bf8]], [[2g4d|2g4d]], [[2io2|2io2]], [[2iy0|2iy0]], [[2iy1|2iy1]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uyz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uyz RCSB], [http://www.ebi.ac.uk/pdbsum/2uyz PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uyz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uyz RCSB], [http://www.ebi.ac.uk/pdbsum/2uyz PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/UBC9_MOUSE UBC9_MOUSE]] Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly-SUMO chains. Essential for nuclear architecture, chromosome segregation and embryonic viability. Necessary for sumoylation of FOXL2 and KAT5 (By similarity).<ref>PMID:16326389</ref> <ref>PMID:17187077</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Ubiquitin--protein ligase]]
[[Category: Ubiquitin--protein ligase]]
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[[Category: Dijk, W J.Van.]]
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[[Category: Dijk, W J.Van]]
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[[Category: Knipscheer, P.]]
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[[Category: Knipscheer, P]]
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[[Category: Mann, M.]]
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[[Category: Mann, M]]
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[[Category: Olsen, J V.]]
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[[Category: Olsen, J V]]
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[[Category: Sixma, T K.]]
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[[Category: Sixma, T K]]
[[Category: Cell cycle]]
[[Category: Cell cycle]]
[[Category: Cell division]]
[[Category: Cell division]]

Revision as of 20:28, 24 December 2014

NON-COVALENT COMPLEX BETWEEN UBC9 AND SUMO1

2uyz, resolution 1.40Å

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