2uvs
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2uvs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Androctonus_mauritanicus Androctonus mauritanicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UVS FirstGlance]. <br> | <table><tr><td colspan='2'>[[2uvs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Androctonus_mauritanicus Androctonus mauritanicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UVS FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ktx|1ktx]], [[2ktx|2ktx]], [[2uvt|2uvt]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ktx|1ktx]], [[2ktx|2ktx]], [[2uvt|2uvt]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uvs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uvs RCSB], [http://www.ebi.ac.uk/pdbsum/2uvs PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uvs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uvs RCSB], [http://www.ebi.ac.uk/pdbsum/2uvs PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KAX31_ANDMA KAX31_ANDMA]] Potent inhibitor of large conductance calcium-activated potassium channels (BK-Ca). Also binds to the dendrotoxin sensitive voltage-dependent potassium channel. It appears to block channel activity by a simple bimolecular inhibition process. Induces a transient period of fast flickering in the channel openings, followed by an almost complete blockade of the channel. Its binding affinity to rat brain synaptosomes is 5-fold higher than this of KTX-3. Binding of the toxin to the channel is associated with significant structural rearrangements in both molecules. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Androctonus mauritanicus]] | [[Category: Androctonus mauritanicus]] | ||
| - | [[Category: Baldus, M | + | [[Category: Baldus, M]] |
| - | [[Category: Becker, S | + | [[Category: Becker, S]] |
| - | [[Category: Korukottu, J | + | [[Category: Korukottu, J]] |
| - | [[Category: Lange, A | + | [[Category: Lange, A]] |
| - | [[Category: Pongs, O | + | [[Category: Pongs, O]] |
| - | [[Category: Schneider, R | + | [[Category: Schneider, R]] |
| - | [[Category: Vijayan, V | + | [[Category: Vijayan, V]] |
| - | [[Category: Zweckstetter, M | + | [[Category: Zweckstetter, M]] |
[[Category: Amidation]] | [[Category: Amidation]] | ||
[[Category: Ionic channel inhibitor]] | [[Category: Ionic channel inhibitor]] | ||
Revision as of 00:09, 25 December 2014
HIGH RESOLUTION SOLID-STATE NMR STRUCTURE OF KALIOTOXIN
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