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4c4x
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4c4x]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C4X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C4X FirstGlance]. <br> | <table><tr><td colspan='2'>[[4c4x]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C4X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C4X FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=W9M:3-(3,4-DICHLOROPHENYL)-1,1-DIMETHYL-UREA'>W9M</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=W9M:3-(3,4-DICHLOROPHENYL)-1,1-DIMETHYL-UREA'>W9M</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c4y|4c4y]], [[4c4z|4c4z]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c4y|4c4y]], [[4c4z|4c4z]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c4x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c4x RCSB], [http://www.ebi.ac.uk/pdbsum/4c4x PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c4x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c4x RCSB], [http://www.ebi.ac.uk/pdbsum/4c4x PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HYES_HUMAN HYES_HUMAN]] Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate.<ref>PMID:12574508</ref> <ref>PMID:12574510</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Becker, S | + | [[Category: Becker, S]] |
| - | [[Category: Elshorst, B | + | [[Category: Elshorst, B]] |
| - | [[Category: Griesinger, C | + | [[Category: Griesinger, C]] |
| - | [[Category: Hessler, G | + | [[Category: Hessler, G]] |
| - | [[Category: Krimm, I | + | [[Category: Krimm, I]] |
| - | [[Category: Langer, T | + | [[Category: Langer, T]] |
| - | [[Category: Lee, D | + | [[Category: Lee, D]] |
| - | [[Category: Mazur, A | + | [[Category: Mazur, A]] |
| - | [[Category: Monecke, P | + | [[Category: Monecke, P]] |
| - | [[Category: Pilger, J | + | [[Category: Pilger, J]] |
| - | [[Category: Schiffer, A | + | [[Category: Schiffer, A]] |
| - | [[Category: Schreuder, H | + | [[Category: Schreuder, H]] |
| - | [[Category: Wegstroth, M | + | [[Category: Wegstroth, M]] |
| - | [[Category: Wendt, K U | + | [[Category: Wendt, K U]] |
[[Category: Drug design]] | [[Category: Drug design]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Multiple binding mode]] | [[Category: Multiple binding mode]] | ||
Revision as of 18:52, 24 December 2014
Crystal structure of human bifunctional epoxide hydroxylase 2 complexed with C9
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Categories: Becker, S | Elshorst, B | Griesinger, C | Hessler, G | Krimm, I | Langer, T | Lee, D | Mazur, A | Monecke, P | Pilger, J | Schiffer, A | Schreuder, H | Wegstroth, M | Wendt, K U | Drug design | Hydrolase | Multiple binding mode
