This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2x93
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2x93]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X93 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2x93]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X93 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=X93:TRANDOLAPRILAT'>X93</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=X93:TRANDOLAPRILAT'>X93</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1j38|1j38]], [[1j36|1j36]], [[1j37|1j37]], [[2x94|2x94]], [[2x8z|2x8z]], [[2x8y|2x8y]], [[2x91|2x91]], [[2x95|2x95]], [[2x92|2x92]], [[2x96|2x96]], [[2x97|2x97]], [[2x90|2x90]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1j38|1j38]], [[1j36|1j36]], [[1j37|1j37]], [[2x94|2x94]], [[2x8z|2x8z]], [[2x8y|2x8y]], [[2x91|2x91]], [[2x95|2x95]], [[2x92|2x92]], [[2x96|2x96]], [[2x97|2x97]], [[2x90|2x90]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidyl-dipeptidase_A Peptidyl-dipeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.15.1 3.4.15.1] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidyl-dipeptidase_A Peptidyl-dipeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.15.1 3.4.15.1] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x93 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x93 RCSB], [http://www.ebi.ac.uk/pdbsum/2x93 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x93 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x93 RCSB], [http://www.ebi.ac.uk/pdbsum/2x93 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ACE_DROME ACE_DROME]] May be involved in the specific maturation or degradation of a number of bioactive peptides. May play a role in the contractions of the heart, gut and testes, and in spermatid differentiation.<ref>PMID:12591244</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 36: | Line 38: | ||
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
[[Category: Peptidyl-dipeptidase A]] | [[Category: Peptidyl-dipeptidase A]] | ||
| - | [[Category: Acharya, K R | + | [[Category: Acharya, K R]] |
| - | [[Category: Akif, M | + | [[Category: Akif, M]] |
| - | [[Category: Dive, V | + | [[Category: Dive, V]] |
| - | [[Category: Georgiadis, D | + | [[Category: Georgiadis, D]] |
| - | [[Category: Isaac, R E | + | [[Category: Isaac, R E]] |
| - | [[Category: Mahajan, A | + | [[Category: Mahajan, A]] |
| - | [[Category: Sturrock, E D | + | [[Category: Sturrock, E D]] |
[[Category: Ace inhibitor]] | [[Category: Ace inhibitor]] | ||
[[Category: Carboxypeptidase]] | [[Category: Carboxypeptidase]] | ||
Revision as of 19:42, 24 December 2014
Crystal structure of AnCE-trandolaprilat complex
| |||||||||||
