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2xcr
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2xcr]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XCR FirstGlance]. <br> | <table><tr><td colspan='2'>[[2xcr]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XCR FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RXV:6-METHOXY-4-(2-{4-[([1,3]OXATHIOLO[5,4-C]PYRIDIN-6-YLMETHYL)AMINO]PIPERIDIN-1-YL}ETHYL)QUINOLINE-3-CARBONITRILE'>RXV</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RXV:6-METHOXY-4-(2-{4-[([1,3]OXATHIOLO[5,4-C]PYRIDIN-6-YLMETHYL)AMINO]PIPERIDIN-1-YL}ETHYL)QUINOLINE-3-CARBONITRILE'>RXV</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5UA:5-O-CARBOXY-2-DEOXYADENOSINE'>5UA</scene></td></tr> | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5UA:5-O-CARBOXY-2-DEOXYADENOSINE'>5UA</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xcs|2xcs]], [[2xct|2xct]], [[2xco|2xco]], [[2xcq|2xcq]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xcs|2xcs]], [[2xct|2xct]], [[2xco|2xco]], [[2xcq|2xcq]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xcr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xcr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xcr RCSB], [http://www.ebi.ac.uk/pdbsum/2xcr PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xcr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xcr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xcr RCSB], [http://www.ebi.ac.uk/pdbsum/2xcr PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GYRB_STAAN GYRB_STAAN]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Staphylococcus aureus]] | [[Category: Staphylococcus aureus]] | ||
| - | [[Category: Bax, B D | + | [[Category: Bax, B D]] |
| - | [[Category: Brown, K K | + | [[Category: Brown, K K]] |
| - | [[Category: Chan, P F | + | [[Category: Chan, P F]] |
| - | [[Category: Eggleston, D S | + | [[Category: Eggleston, D S]] |
| - | [[Category: Fosberry, A | + | [[Category: Fosberry, A]] |
| - | [[Category: Gentry, D R | + | [[Category: Gentry, D R]] |
| - | [[Category: Giordano, I | + | [[Category: Giordano, I]] |
| - | [[Category: Gorrec, F | + | [[Category: Gorrec, F]] |
| - | [[Category: Gwynn, M N | + | [[Category: Gwynn, M N]] |
| - | [[Category: Hann, M M | + | [[Category: Hann, M M]] |
| - | [[Category: Hennessy, A | + | [[Category: Hennessy, A]] |
| - | [[Category: Hibbs, M | + | [[Category: Hibbs, M]] |
| - | [[Category: Huang, J | + | [[Category: Huang, J]] |
| - | [[Category: Jones, E | + | [[Category: Jones, E]] |
| - | [[Category: Jones, J | + | [[Category: Jones, J]] |
| - | [[Category: Lewis, C J | + | [[Category: Lewis, C J]] |
| - | [[Category: May, E W | + | [[Category: May, E W]] |
| - | [[Category: Pearson, N D | + | [[Category: Pearson, N D]] |
| - | [[Category: Shen, C | + | [[Category: Shen, C]] |
| - | [[Category: Shillings, A | + | [[Category: Shillings, A]] |
| - | [[Category: Singh, O | + | [[Category: Singh, O]] |
| - | [[Category: Spitzfaden, C | + | [[Category: Spitzfaden, C]] |
| - | [[Category: Theobald, A F | + | [[Category: Theobald, A F]] |
| - | [[Category: Wohlkonig, A | + | [[Category: Wohlkonig, A]] |
[[Category: Isomerase]] | [[Category: Isomerase]] | ||
Revision as of 09:57, 25 December 2014
THE 3.5A CRYSTAL STRUCTURE OF THE CATALYTIC CORE (B'A' REGION) OF STAPHYLOCOCCUS AUREUS DNA GYRASE COMPLEXED WITH GSK299423 AND DNA
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Categories: Staphylococcus aureus | Bax, B D | Brown, K K | Chan, P F | Eggleston, D S | Fosberry, A | Gentry, D R | Giordano, I | Gorrec, F | Gwynn, M N | Hann, M M | Hennessy, A | Hibbs, M | Huang, J | Jones, E | Jones, J | Lewis, C J | May, E W | Pearson, N D | Shen, C | Shillings, A | Singh, O | Spitzfaden, C | Theobald, A F | Wohlkonig, A | Isomerase
