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2x90
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2x90]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X90 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X90 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2x90]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X90 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X90 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EAL:1-((2S)-2-{[(1S)-1-CARBOXY-3-PHENYLPROPYL]AMINO}PROPANOYL)-L-PROLINE'>EAL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EAL:1-((2S)-2-{[(1S)-1-CARBOXY-3-PHENYLPROPYL]AMINO}PROPANOYL)-L-PROLINE'>EAL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1j38|1j38]], [[1j36|1j36]], [[1j37|1j37]], [[2x94|2x94]], [[2x8z|2x8z]], [[2x8y|2x8y]], [[2x91|2x91]], [[2x95|2x95]], [[2x92|2x92]], [[2x96|2x96]], [[2x97|2x97]], [[2x93|2x93]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1j38|1j38]], [[1j36|1j36]], [[1j37|1j37]], [[2x94|2x94]], [[2x8z|2x8z]], [[2x8y|2x8y]], [[2x91|2x91]], [[2x95|2x95]], [[2x92|2x92]], [[2x96|2x96]], [[2x97|2x97]], [[2x93|2x93]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidyl-dipeptidase_A Peptidyl-dipeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.15.1 3.4.15.1] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidyl-dipeptidase_A Peptidyl-dipeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.15.1 3.4.15.1] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x90 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x90 RCSB], [http://www.ebi.ac.uk/pdbsum/2x90 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x90 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x90 RCSB], [http://www.ebi.ac.uk/pdbsum/2x90 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ACE_DROME ACE_DROME]] May be involved in the specific maturation or degradation of a number of bioactive peptides. May play a role in the contractions of the heart, gut and testes, and in spermatid differentiation.<ref>PMID:12591244</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
[[Category: Peptidyl-dipeptidase A]] | [[Category: Peptidyl-dipeptidase A]] | ||
| - | [[Category: Acharya, K R | + | [[Category: Acharya, K R]] |
| - | [[Category: Akif, M | + | [[Category: Akif, M]] |
| - | [[Category: Dive, V | + | [[Category: Dive, V]] |
| - | [[Category: Georgiadis, D | + | [[Category: Georgiadis, D]] |
| - | [[Category: Isaac, R E | + | [[Category: Isaac, R E]] |
| - | [[Category: Mahajan, A | + | [[Category: Mahajan, A]] |
| - | [[Category: Sturrock, E D | + | [[Category: Sturrock, E D]] |
[[Category: Ace inhibitor]] | [[Category: Ace inhibitor]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Zinc metallopeptidase]] | [[Category: Zinc metallopeptidase]] | ||
Revision as of 01:55, 25 December 2014
CRYSTAL STRUCTURE OF ANCE-ENALAPRILAT COMPLEX
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