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3bw9

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3bw9]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BW9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BW9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3bw9]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BW9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BW9 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3bwa|3bwa]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3bwa|3bwa]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bw9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bw9 RCSB], [http://www.ebi.ac.uk/pdbsum/3bw9 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bw9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bw9 RCSB], [http://www.ebi.ac.uk/pdbsum/3bw9 PDBsum]</span></td></tr>
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<table>
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</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Archbold, J K.]]
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[[Category: Archbold, J K]]
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[[Category: Burrows, S R.]]
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[[Category: Burrows, S R]]
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[[Category: Cooper, L.]]
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[[Category: Cooper, L]]
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[[Category: Gras, S.]]
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[[Category: Gras, S]]
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[[Category: Khanna, R.]]
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[[Category: Khanna, R]]
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[[Category: Marland, Z.]]
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[[Category: Marland, Z]]
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[[Category: McCluskey, J.]]
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[[Category: McCluskey, J]]
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[[Category: Miles, J J.]]
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[[Category: Miles, J J]]
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[[Category: Rossjohn, J.]]
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[[Category: Rossjohn, J]]
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[[Category: Silins, S L.]]
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[[Category: Silins, S L]]
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[[Category: Tynan, F E.]]
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[[Category: Tynan, F E]]
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[[Category: Wynn, K K.]]
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[[Category: Wynn, K K]]
[[Category: Disease mutation]]
[[Category: Disease mutation]]
[[Category: Glycation]]
[[Category: Glycation]]

Revision as of 11:10, 20 January 2015

Crystal Structure of HLA B*3508 in complex with a HCMV 12-mer peptide from the pp65 protein

3bw9, resolution 1.75Å

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