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3baf
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3baf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BAF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BAF FirstGlance]. <br> | <table><tr><td colspan='2'>[[3baf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BAF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BAF FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=SKM:(3R,4S,5R)-3,4,5-TRIHYDROXYCYCLOHEX-1-ENE-1-CARBOXYLIC+ACID'>SKM</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=SKM:(3R,4S,5R)-3,4,5-TRIHYDROXYCYCLOHEX-1-ENE-1-CARBOXYLIC+ACID'>SKM</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aroK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aroK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3baf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3baf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3baf RCSB], [http://www.ebi.ac.uk/pdbsum/3baf PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3baf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3baf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3baf RCSB], [http://www.ebi.ac.uk/pdbsum/3baf PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/AROK_MYCTU AROK_MYCTU]] Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.<ref>PMID:11483005</ref> <ref>PMID:17020768</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Shikimate kinase|Shikimate kinase]] | *[[Shikimate kinase|Shikimate kinase]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: Shikimate kinase]] | [[Category: Shikimate kinase]] | ||
| - | [[Category: Azevedo, W F | + | [[Category: Azevedo, W F]] |
| - | [[Category: Basso, L A | + | [[Category: Basso, L A]] |
| - | [[Category: Dias, M V.B | + | [[Category: Dias, M V.B]] |
| - | [[Category: Faim, L M | + | [[Category: Faim, L M]] |
| - | [[Category: Ruggiero, N J | + | [[Category: Ruggiero, N J]] |
| - | [[Category: Santos, D S | + | [[Category: Santos, D S]] |
| - | [[Category: Vasconcelos, I G | + | [[Category: Vasconcelos, I G]] |
[[Category: Amino-acid biosynthesis]] | [[Category: Amino-acid biosynthesis]] | ||
[[Category: Amp-pnp]] | [[Category: Amp-pnp]] | ||
| Line 39: | Line 43: | ||
[[Category: Metal-binding]] | [[Category: Metal-binding]] | ||
[[Category: Nucleotide-binding]] | [[Category: Nucleotide-binding]] | ||
| - | [[Category: Shikimate kinase]] | ||
[[Category: Shikimate pathway]] | [[Category: Shikimate pathway]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 08:08, 25 December 2014
Crystal structure of shikimate kinase from Mycobacterium tuberculosis in complex with AMP-PNP
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Categories: Mycobacterium tuberculosis | Shikimate kinase | Azevedo, W F | Basso, L A | Dias, M V.B | Faim, L M | Ruggiero, N J | Santos, D S | Vasconcelos, I G | Amino-acid biosynthesis | Amp-pnp | Aromatic amino acid biosynthesis | Atp-binding | Magnesium | Metal-binding | Nucleotide-binding | Shikimate pathway | Transferase
