3cey

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3cey]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CEY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CEY FirstGlance]. <br>
<table><tr><td colspan='2'>[[3cey]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CEY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CEY FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">L3MBTL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">L3MBTL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cey OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cey RCSB], [http://www.ebi.ac.uk/pdbsum/3cey PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cey OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cey RCSB], [http://www.ebi.ac.uk/pdbsum/3cey PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/LMBL2_HUMAN LMBL2_HUMAN]] Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.<ref>PMID:19233876</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Allali-Hassani, A.]]
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[[Category: Allali-Hassani, A]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith, C H]]
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[[Category: Bochkarev, A.]]
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[[Category: Bochkarev, A]]
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[[Category: Bountra, C.]]
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[[Category: Bountra, C]]
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[[Category: Crombet, L.]]
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[[Category: Crombet, L]]
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[[Category: Dong, A.]]
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[[Category: Dong, A]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards, A M]]
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[[Category: Guo, Y.]]
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[[Category: Guo, Y]]
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[[Category: Kozieradzki, I.]]
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[[Category: Kozieradzki, I]]
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[[Category: Loppnau, P.]]
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[[Category: Loppnau, P]]
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[[Category: Mackenzie, F.]]
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[[Category: Mackenzie, F]]
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[[Category: Min, J.]]
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[[Category: Min, J]]
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[[Category: Nady, N.]]
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[[Category: Nady, N]]
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[[Category: Pan, P.]]
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[[Category: Pan, P]]
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[[Category: Qi, C.]]
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[[Category: Qi, C]]
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[[Category: Read, R.]]
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[[Category: Read, R]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Structural genomic]]
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[[Category: Vedadi, M.]]
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[[Category: Vedadi, M]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt, J]]
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[[Category: Zhu, H.]]
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[[Category: Zhu, H]]
[[Category: Chromatin regulator]]
[[Category: Chromatin regulator]]
[[Category: Mbt]]
[[Category: Mbt]]
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[[Category: Nucleus]]
[[Category: Nucleus]]
[[Category: Sgc]]
[[Category: Sgc]]
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[[Category: Structural genomic]]
 
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[[Category: Structural genomics consortium]]
 
[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
[[Category: Transcription regulator]]
[[Category: Transcription regulator]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]

Revision as of 02:33, 25 December 2014

Crystal structure of L3MBTL2

3cey, resolution 2.20Å

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