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1usx
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1usx]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Avian_paramyxovirus_type_1 Avian paramyxovirus type 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1USX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1USX FirstGlance]. <br> | <table><tr><td colspan='2'>[[1usx]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Avian_paramyxovirus_type_1 Avian paramyxovirus type 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1USX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1USX FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAN:2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC+ACID'>DAN</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=WIA:METHYL(6S)-1-THIO-L-MANNO-HEXODIALDO-6,2-PYRANOSIDE'>WIA</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAN:2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC+ACID'>DAN</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=WIA:METHYL(6S)-1-THIO-L-MANNO-HEXODIALDO-6,2-PYRANOSIDE'>WIA</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1e8t|1e8t]], [[1e8u|1e8u]], [[1e8v|1e8v]], [[1usr|1usr]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1e8t|1e8t]], [[1e8u|1e8u]], [[1e8v|1e8v]], [[1usr|1usr]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1usx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1usx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1usx RCSB], [http://www.ebi.ac.uk/pdbsum/1usx PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1usx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1usx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1usx RCSB], [http://www.ebi.ac.uk/pdbsum/1usx PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HN_NDVB HN_NDVB]] Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity). Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Avian paramyxovirus type 1]] | [[Category: Avian paramyxovirus type 1]] | ||
[[Category: Exo-alpha-sialidase]] | [[Category: Exo-alpha-sialidase]] | ||
| - | [[Category: Groves, D | + | [[Category: Groves, D]] |
| - | [[Category: Itzstein, M | + | [[Category: Itzstein, M]] |
| - | [[Category: Kiefel, M | + | [[Category: Kiefel, M]] |
| - | [[Category: Portner, A | + | [[Category: Portner, A]] |
| - | [[Category: Takimoto, T | + | [[Category: Takimoto, T]] |
| - | [[Category: Taylor, G | + | [[Category: Taylor, G]] |
| - | [[Category: Zaitsev, V | + | [[Category: Zaitsev, V]] |
[[Category: Hemagglutinin]] | [[Category: Hemagglutinin]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Neuraminidase]] | [[Category: Neuraminidase]] | ||
[[Category: Sialidase]] | [[Category: Sialidase]] | ||
Revision as of 12:46, 25 December 2014
Crystal structure of the Newcastle disease virus hemagglutinin-neuraminidase complexed with thiosialoside
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