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1sqn
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1sqn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SQN FirstGlance]. <br> | <table><tr><td colspan='2'>[[1sqn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SQN FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NDR:(14BETA,17ALPHA)-17-ETHYNYL-17-HYDROXYESTR-4-EN-3-ONE'>NDR</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NDR:(14BETA,17ALPHA)-17-ETHYNYL-17-HYDROXYESTR-4-EN-3-ONE'>NDR</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a28|1a28]], [[1e3k|1e3k]], [[1zyx|1zyx]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a28|1a28]], [[1e3k|1e3k]], [[1zyx|1zyx]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HUMPGRR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HUMPGRR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sqn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sqn RCSB], [http://www.ebi.ac.uk/pdbsum/1sqn PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sqn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sqn RCSB], [http://www.ebi.ac.uk/pdbsum/1sqn PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PRGR_HUMAN PRGR_HUMAN]] The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Austin, R J.H | + | [[Category: Austin, R J.H]] |
| - | [[Category: Deng, J S | + | [[Category: Deng, J S]] |
| - | [[Category: Lambert, M H | + | [[Category: Lambert, M H]] |
| - | [[Category: Madauss, K P | + | [[Category: Madauss, K P]] |
| - | [[Category: McLay, I | + | [[Category: McLay, I]] |
| - | [[Category: Pritchard, J | + | [[Category: Pritchard, J]] |
| - | [[Category: Short, S A | + | [[Category: Short, S A]] |
| - | [[Category: Stewart, E L | + | [[Category: Stewart, E L]] |
| - | [[Category: Uings, I J | + | [[Category: Uings, I J]] |
| - | [[Category: Williams, S P | + | [[Category: Williams, S P]] |
[[Category: Birth control]] | [[Category: Birth control]] | ||
[[Category: Hormone-growth factor receptor complex]] | [[Category: Hormone-growth factor receptor complex]] | ||
Revision as of 14:04, 24 December 2014
Progesterone Receptor Ligand Binding Domain with bound Norethindrone
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Categories: Homo sapiens | Austin, R J.H | Deng, J S | Lambert, M H | Madauss, K P | McLay, I | Pritchard, J | Short, S A | Stewart, E L | Uings, I J | Williams, S P | Birth control | Hormone-growth factor receptor complex | Norethindrone | Nuclear receptor | Progesterone receptor | Steroid receptor
