1j6s
From Proteopedia
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|PDB= 1j6s |SIZE=350|CAPTION= <scene name='initialview01'>1j6s</scene>, resolution 1.4Å | |PDB= 1j6s |SIZE=350|CAPTION= <scene name='initialview01'>1j6s</scene>, resolution 1.4Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=BA:BARIUM+ION'>BA</scene> | + | |LIGAND= <scene name='pdbligand=A:ADENOSINE-5'-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=BRU:5-BROMO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE'>BRU</scene>, <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=U:URIDINE-5'-MONOPHOSPHATE'>U</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j6s OCA], [http://www.ebi.ac.uk/pdbsum/1j6s PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1j6s RCSB]</span> | ||
}} | }} | ||
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[[Category: Sundaralingam, M.]] | [[Category: Sundaralingam, M.]] | ||
[[Category: Xiong, Y.]] | [[Category: Xiong, Y.]] | ||
| - | [[Category: BA]] | ||
| - | [[Category: NA]] | ||
[[Category: a-tetrad]] | [[Category: a-tetrad]] | ||
[[Category: g-tetrad]] | [[Category: g-tetrad]] | ||
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[[Category: u-tetrad]] | [[Category: u-tetrad]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:29:18 2008'' |
Revision as of 18:29, 30 March 2008
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| , resolution 1.4Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of an RNA Tetraplex (UGAGGU)4 with A-tetrads, G-tetrads, U-tetrads and G-U octads
Overview
Purine-rich regions in DNA and RNA may contain both guanines and adenines, which have various biological functions. Here we report the crystal structure of an RNA purine-rich fragment containing both guanine and adenine at 1.4 A resolution. Adenines form an adenine tetrad in the N6-H em leader N7 conformation. Substitution of an adenine tetrad in the guanine tetraplex does not change the global conformation but introduces irregularity in both the hydrogen bonding interaction pattern in the groove and the metal ion binding pattern in the central cavity of the tetraplex. The irregularity in groove binding may be critical for specific binding in tetraplexes. The formation of G-U octads provides a mechanism for interaction in the groove. Ba(2+) ions prefer to bind guanine tetrads, and adenine tetrads can only be bound by Na(+) ions, illustrating the binding selectivity of metal ions for the tetraplex.
About this Structure
1J6S is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Crystal structure of an RNA purine-rich tetraplex containing adenine tetrads: implications for specific binding in RNA tetraplexes., Pan B, Xiong Y, Shi K, Deng J, Sundaralingam M, Structure. 2003 Jul;11(7):815-23. PMID:12842044
Page seeded by OCA on Sun Mar 30 21:29:18 2008
Categories: Protein complex | Deng, J. | Pan, B. | Shi, K. | Sundaralingam, M. | Xiong, Y. | A-tetrad | G-tetrad | G-u octad | Rna | Tetraplex | U-tetrad
