2atb
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2atb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leiurus_quinquestriatus Leiurus quinquestriatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ATB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ATB FirstGlance]. <br> | <table><tr><td colspan='2'>[[2atb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leiurus_quinquestriatus Leiurus quinquestriatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ATB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ATB FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2asc|2asc]], [[1lqh|1lqh]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2asc|2asc]], [[1lqh|1lqh]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2atb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2atb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2atb RCSB], [http://www.ebi.ac.uk/pdbsum/2atb PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2atb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2atb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2atb RCSB], [http://www.ebi.ac.uk/pdbsum/2atb PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SCXA_LEIQH SCXA_LEIQH]] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. The dissociation is voltage-dependent. This toxin is active on insects. It is also highly toxic to crustaceans and has a measurable but low toxicity to mice. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Leiurus quinquestriatus]] | [[Category: Leiurus quinquestriatus]] | ||
| - | [[Category: Frolow, F | + | [[Category: Frolow, F]] |
| - | [[Category: Gurevitz, M | + | [[Category: Gurevitz, M]] |
| - | [[Category: Kahn, R | + | [[Category: Kahn, R]] |
| - | [[Category: Karbat, I | + | [[Category: Karbat, I]] |
[[Category: Alpha toxin]] | [[Category: Alpha toxin]] | ||
[[Category: Muation]] | [[Category: Muation]] | ||
[[Category: Scorpion]] | [[Category: Scorpion]] | ||
[[Category: Toxin]] | [[Category: Toxin]] | ||
Revision as of 16:56, 24 December 2014
Triple mutant 8D9D10V of scorpion toxin LQH-alpha-IT
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Categories: Leiurus quinquestriatus | Frolow, F | Gurevitz, M | Kahn, R | Karbat, I | Alpha toxin | Muation | Scorpion | Toxin
