4rg2
From Proteopedia
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| - | ''' | + | ==Tudor Domain of Tumor suppressor p53BP1 with small molecule ligand== |
| - | + | <StructureSection load='4rg2' size='340' side='right' caption='[[4rg2]], [[Resolution|resolution]] 1.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4rg2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RG2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RG2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3OO:3-BROMO-N-[3-(TERT-BUTYLAMINO)PROPYL]BENZAMIDE'>3OO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rg2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rg2 RCSB], [http://www.ebi.ac.uk/pdbsum/4rg2 PDBsum]</span></td></tr> | |
| - | + | </table> | |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arrowsmith, C H.]] | ||
| + | [[Category: Bountra, C.]] | ||
| + | [[Category: Brown, P J.]] | ||
| + | [[Category: Dong, A.]] | ||
| + | [[Category: Edwards, A M.]] | ||
| + | [[Category: Frye, S.]] | ||
| + | [[Category: James, L.]] | ||
| + | [[Category: Mader, P.]] | ||
| + | [[Category: Perfetti, M.]] | ||
| + | [[Category: SGC, Structural Genomics Consortium.]] | ||
| + | [[Category: Tempel, W.]] | ||
| + | [[Category: 53bp1 tudor]] | ||
| + | [[Category: Sgc]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Structural genomics consortium]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 11:03, 20 October 2014
Tudor Domain of Tumor suppressor p53BP1 with small molecule ligand
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