1jd5
From Proteopedia
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|PDB= 1jd5 |SIZE=350|CAPTION= <scene name='initialview01'>1jd5</scene>, resolution 1.9Å | |PDB= 1jd5 |SIZE=350|CAPTION= <scene name='initialview01'>1jd5</scene>, resolution 1.9Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | + | |LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= DIAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster]) | |GENE= DIAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1jd4|1JD4]], [[1jd6|1JD6]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jd5 OCA], [http://www.ebi.ac.uk/pdbsum/1jd5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jd5 RCSB]</span> | ||
}} | }} | ||
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[[Category: Shi, Y.]] | [[Category: Shi, Y.]] | ||
[[Category: Wu, J W.]] | [[Category: Wu, J W.]] | ||
| - | [[Category: ZN]] | ||
[[Category: apoptosis]] | [[Category: apoptosis]] | ||
[[Category: caspase activation]] | [[Category: caspase activation]] | ||
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[[Category: iap]] | [[Category: iap]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:31:57 2008'' |
Revision as of 18:31, 30 March 2008
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| , resolution 1.9Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | DIAP1 (Drosophila melanogaster) | ||||||
| Related: | 1JD4, 1JD6
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of DIAP1-BIR2/GRIM
Overview
The inhibitor of apoptosis protein DIAP1 suppresses apoptosis in Drosophila, with the second BIR domain (BIR2) playing an important role. Three proteins, Hid, Grim, and Reaper, promote apoptosis, in part by binding to DIAP1 through their conserved N-terminal sequences. The crystal structures of DIAP1-BIR2 by itself and in complex with the N-terminal peptides from Hid and Grim reveal that these peptides bind a surface groove on DIAP1, with the first four amino acids mimicking the binding of the Smac tetrapeptide to XIAP. The next 3 residues also contribute to binding through hydrophobic interactions. Interestingly, peptide binding induces the formation of an additional alpha helix in DIAP1. Our study reveals the structural conservation and diversity necessary for the binding of IAPs by the Drosophila Hid/Grim/Reaper and the mammalian Smac proteins.
About this Structure
1JD5 is a Protein complex structure of sequences from Drosophila melanogaster. Full crystallographic information is available from OCA.
Reference
Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides., Wu JW, Cocina AE, Chai J, Hay BA, Shi Y, Mol Cell. 2001 Jul;8(1):95-104. PMID:11511363
Page seeded by OCA on Sun Mar 30 21:31:57 2008
Categories: Drosophila melanogaster | Protein complex | Chai, J. | Cocina, A E. | Hay, B A. | Shi, Y. | Wu, J W. | Apoptosis | Caspase activation | Drosophila | Grim | Iap
