4qiw

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qiw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qiw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qiw RCSB], [http://www.ebi.ac.uk/pdbsum/4qiw PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qiw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qiw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qiw RCSB], [http://www.ebi.ac.uk/pdbsum/4qiw PDBsum]</span></td></tr>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The archaeal transcription apparatus is closely related to the eukaryotic RNA polymerase II (Pol II) system. Archaeal RNA polymerase (RNAP) and Pol II evolved from a common ancestral structure and the euryarchaeal RNAP is the simplest member of the extant archaeal-eukaryotic RNAP family. Here we report the first crystal structure of euryarchaeal RNAP from Thermococcus kodakarensis (Tko). This structure reveals that the clamp domain is able to swing away from the main body of RNAP in the presence of the Rpo4/Rpo7 stalk by coordinated movements of these domains. More detailed structure-function analysis of yeast Pol II and Tko RNAP identifies structural additions to Pol II that correspond to the binding sites of Pol II-specific general transcription factors including TFIIF, TFIIH and Mediator. Such comparisons provide a framework for dissecting interactions between RNAP and these factors during formation of the pre-initiation complex.
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The X-ray crystal structure of the euryarchaeal RNA polymerase in an open-clamp configuration.,Jun SH, Hirata A, Kanai T, Santangelo TJ, Imanaka T, Murakami KS Nat Commun. 2014 Oct 14;5:5132. doi: 10.1038/ncomms6132. PMID:25311937<ref>PMID:25311937</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: DNA-directed RNA polymerase]]
[[Category: DNA-directed RNA polymerase]]
[[Category: Thermococcus kodakarensis]]
[[Category: Thermococcus kodakarensis]]
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[[Category: Jun, S H.]]
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[[Category: Jun, S H]]
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[[Category: Murakami, K S.]]
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[[Category: Murakami, K S]]
[[Category: Dna-directed rna polymerase]]
[[Category: Dna-directed rna polymerase]]
[[Category: Transcription]]
[[Category: Transcription]]

Revision as of 06:16, 26 November 2014

Crystal structure of euryarchaeal RNA polymerase from Thermococcus kodakarensis

4qiw, resolution 3.50Å

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