1jes

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|PDB= 1jes |SIZE=350|CAPTION= <scene name='initialview01'>1jes</scene>, resolution 1.5&Aring;
|PDB= 1jes |SIZE=350|CAPTION= <scene name='initialview01'>1jes</scene>, resolution 1.5&Aring;
|SITE=
|SITE=
-
|LIGAND= <scene name='pdbligand=CU:COPPER (II) ION'>CU</scene>
+
|LIGAND= <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DPY:2-DEOXYRIBOFURANOSYL-PYRIDINE-2,6-DICARBOXYLIC+ACID-5&#39;-MONOPHOSPHATE'>DPY</scene>, <scene name='pdbligand=DRP:2-DEOXYRIBOFURANOSYL-PYRIDINE-5&#39;-MONOPHOSPHATE'>DRP</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
 +
|DOMAIN=
 +
|RELATEDENTRY=[[1bna|1BNA]], [[2zna|2ZNA]], [[3zna|3ZNA]]
 +
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jes OCA], [http://www.ebi.ac.uk/pdbsum/1jes PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jes RCSB]</span>
}}
}}
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[[Category: Schultz, P G.]]
[[Category: Schultz, P G.]]
[[Category: Spraggon, G.]]
[[Category: Spraggon, G.]]
-
[[Category: CU]]
 
[[Category: copper]]
[[Category: copper]]
[[Category: cu]]
[[Category: cu]]
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[[Category: z-dna]]
[[Category: z-dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:02:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:32:44 2008''

Revision as of 18:32, 30 March 2008

Image:1jes.gif


PDB ID 1jes

Drag the structure with the mouse to rotate
, resolution 1.5Å
Ligands: , , , , , ,
Related: 1BNA, 2ZNA, 3ZNA


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of a Copper-Mediated Base Pair in DNA


Overview

Stable and selective DNA base pairing by metal coordination was recently demonstrated with nucleotides containing complementary pyridine-2,6-dicarboxylate (Dipic) and pyridine (Py) bases (Meggers, E.; Holland, P. L.; Tolman; W. B.; Romesberg, F. E.; Schultz, P. G. J. Am. Chem. Soc. 2000, 122, 10714-10715). To understand the structural consequences of introducing this novel base pair into DNA we have solved the crystal structure of a duplex containing the metallo-base pair. The structure shows that the bases pair as designed, but in a Z-DNA conformation. The structure also provides a structural explanation for the B- to Z-DNA transition in this duplex. Further solution studies demonstrate that the metallo-base pair is compatible with Z- or B-DNA conformations, depending on the duplex sequence.

About this Structure

1JES is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Structure of a copper-mediated base pair in DNA., Atwell S, Meggers E, Spraggon G, Schultz PG, J Am Chem Soc. 2001 Dec 12;123(49):12364-7. PMID:11734038

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