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1jes
From Proteopedia
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|PDB= 1jes |SIZE=350|CAPTION= <scene name='initialview01'>1jes</scene>, resolution 1.5Å | |PDB= 1jes |SIZE=350|CAPTION= <scene name='initialview01'>1jes</scene>, resolution 1.5Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=CU:COPPER (II) ION'>CU</scene> | + | |LIGAND= <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=DA:2'-DEOXYADENOSINE-5'-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DPY:2-DEOXYRIBOFURANOSYL-PYRIDINE-2,6-DICARBOXYLIC+ACID-5'-MONOPHOSPHATE'>DPY</scene>, <scene name='pdbligand=DRP:2-DEOXYRIBOFURANOSYL-PYRIDINE-5'-MONOPHOSPHATE'>DRP</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1bna|1BNA]], [[2zna|2ZNA]], [[3zna|3ZNA]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jes OCA], [http://www.ebi.ac.uk/pdbsum/1jes PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jes RCSB]</span> | ||
}} | }} | ||
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[[Category: Schultz, P G.]] | [[Category: Schultz, P G.]] | ||
[[Category: Spraggon, G.]] | [[Category: Spraggon, G.]] | ||
| - | [[Category: CU]] | ||
[[Category: copper]] | [[Category: copper]] | ||
[[Category: cu]] | [[Category: cu]] | ||
| Line 36: | Line 38: | ||
[[Category: z-dna]] | [[Category: z-dna]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:32:44 2008'' |
Revision as of 18:32, 30 March 2008
| |||||||
| , resolution 1.5Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , , , , | ||||||
| Related: | 1BNA, 2ZNA, 3ZNA
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of a Copper-Mediated Base Pair in DNA
Overview
Stable and selective DNA base pairing by metal coordination was recently demonstrated with nucleotides containing complementary pyridine-2,6-dicarboxylate (Dipic) and pyridine (Py) bases (Meggers, E.; Holland, P. L.; Tolman; W. B.; Romesberg, F. E.; Schultz, P. G. J. Am. Chem. Soc. 2000, 122, 10714-10715). To understand the structural consequences of introducing this novel base pair into DNA we have solved the crystal structure of a duplex containing the metallo-base pair. The structure shows that the bases pair as designed, but in a Z-DNA conformation. The structure also provides a structural explanation for the B- to Z-DNA transition in this duplex. Further solution studies demonstrate that the metallo-base pair is compatible with Z- or B-DNA conformations, depending on the duplex sequence.
About this Structure
1JES is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Structure of a copper-mediated base pair in DNA., Atwell S, Meggers E, Spraggon G, Schultz PG, J Am Chem Soc. 2001 Dec 12;123(49):12364-7. PMID:11734038
Page seeded by OCA on Sun Mar 30 21:32:44 2008
Categories: Protein complex | Atwell, S. | Meggers, E. | Schultz, P G. | Spraggon, G. | Copper | Cu | Designed | Dna | Dodecamer | Duplex | Metal | Unnatural | Z-dna
