1tg8
From Proteopedia
(Difference between revisions)
| Line 7: | Line 7: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tg8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tg8 RCSB], [http://www.ebi.ac.uk/pdbsum/1tg8 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tg8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tg8 RCSB], [http://www.ebi.ac.uk/pdbsum/1tg8 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/POLG_DEN2T POLG_DEN2T]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity). Non-structural protein 1 is involved in virus replication and regulation of the innate immune response. Soluble and membrane-associated NS1 may activate human complement and induce host vascular leakage. This effect might explain the clinical manifestations of dengue hemorrhagic fever and dengue shock syndrome (By similarity). Non-structural protein 2A may be involved viral RNA replication and capsid assembly (Potential). Non-structural protein 2B is a required cofactor for the serine protease function of NS3 (By similarity). Serine protease NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS2B, performs its autocleavage and cleaves the polyprotein at dibasic sites in the cytoplasm: C-prM, NS2A-NS2B, NS2B-NS3, NS3-NS4A, NS4A-2K and NS4B-NS5. NS3 RNA helicase binds RNA and unwinds dsRNA in the 3' to 5' direction (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 20: | Line 22: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Dengue virus 2]] | [[Category: Dengue virus 2]] | ||
| - | [[Category: Baker, T S | + | [[Category: Baker, T S]] |
| - | [[Category: Clements, D | + | [[Category: Clements, D]] |
| - | [[Category: Ogata, S | + | [[Category: Ogata, S]] |
| - | [[Category: Rossmann, M G | + | [[Category: Rossmann, M G]] |
| - | [[Category: Strauss, J H | + | [[Category: Strauss, J H]] |
| - | [[Category: Zhang, W | + | [[Category: Zhang, W]] |
| - | [[Category: Zhang, Y | + | [[Category: Zhang, Y]] |
[[Category: Flavivirus e conformation]] | [[Category: Flavivirus e conformation]] | ||
[[Category: Viral protein]] | [[Category: Viral protein]] | ||
Revision as of 10:41, 25 December 2014
The structure of Dengue virus E glycoprotein
| |||||||||||
