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1q5z
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q5z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q5z RCSB], [http://www.ebi.ac.uk/pdbsum/1q5z PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q5z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q5z RCSB], [http://www.ebi.ac.uk/pdbsum/1q5z PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SIPA_SALTY SIPA_SALTY]] Actin-binding protein that interferes with host cell actin cytoskeleton. It stimulates actin polymerization and counteracts F-actin destabilizing proteins. Potentiates SipC activity; both are required for an efficient bacterial internalization. In vitro, forms a complex with host cell protein T-plastin increasing actin bundling. It inhibits ADF/cofilin-directed depolymerization both by preventing binding of ADF and cofilin and by displacing them from F-actin. Also protects F-actin from gelsolin-directed severing and reanneals gelsolin-severed F-actin fragments.<ref>PMID:10092234</ref> <ref>PMID:14992720</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Salmonella enterica subsp. enterica serovar typhimurium]] | [[Category: Salmonella enterica subsp. enterica serovar typhimurium]] | ||
| - | [[Category: Egelman, E H | + | [[Category: Egelman, E H]] |
| - | [[Category: Galkin, V E | + | [[Category: Galkin, V E]] |
| - | [[Category: Lilic, M | + | [[Category: Lilic, M]] |
| - | [[Category: Orlova, A | + | [[Category: Orlova, A]] |
| - | [[Category: Stebbins, C E | + | [[Category: Stebbins, C E]] |
| - | [[Category: VanLoock, M S | + | [[Category: VanLoock, M S]] |
[[Category: Cell invasion]] | [[Category: Cell invasion]] | ||
Revision as of 11:03, 25 December 2014
Crystal Structure of the C-terminal Actin Binding Domain of Salmonella Invasion Protein A (SipA)
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