1znm
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1znm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1znm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1znm RCSB], [http://www.ebi.ac.uk/pdbsum/1znm PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1znm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1znm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1znm RCSB], [http://www.ebi.ac.uk/pdbsum/1znm PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TYY1_HUMAN TYY1_HUMAN]] Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions).<ref>PMID:17721549</ref> <ref>PMID:18026119</ref> Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements.<ref>PMID:17721549</ref> <ref>PMID:18026119</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Doyle, P M | + | [[Category: Doyle, P M]] |
| - | [[Category: Harris, C J | + | [[Category: Harris, C J]] |
| - | [[Category: Justice, D E | + | [[Category: Justice, D E]] |
| - | [[Category: Mitchell, J B.O | + | [[Category: Mitchell, J B.O]] |
| - | [[Category: Moody, C M | + | [[Category: Moody, C M]] |
| - | [[Category: Patel, S U | + | [[Category: Patel, S U]] |
| - | [[Category: Sadler, P J | + | [[Category: Sadler, P J]] |
| - | [[Category: Thornton, J M | + | [[Category: Thornton, J M]] |
| - | [[Category: Uppenbrink, J | + | [[Category: Uppenbrink, J]] |
| - | [[Category: Viles, J H | + | [[Category: Viles, J H]] |
[[Category: Beta-turn mimetic]] | [[Category: Beta-turn mimetic]] | ||
[[Category: Transcription regulation]] | [[Category: Transcription regulation]] | ||
[[Category: Zinc finger]] | [[Category: Zinc finger]] | ||
Revision as of 20:50, 25 December 2014
A zinc finger with an artificial beta-turn, original sequence taken from the third zinc finger domain of the human transcriptional repressor protein YY1 (YING and YANG 1, a delta transcription factor), nmr, 34 structures
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