1jg5
From Proteopedia
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|PDB= 1jg5 |SIZE=350|CAPTION= <scene name='initialview01'>1jg5</scene>, resolution 2.6Å | |PDB= 1jg5 |SIZE=350|CAPTION= <scene name='initialview01'>1jg5</scene>, resolution 2.6Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=K:POTASSIUM ION'>K</scene> | + | |LIGAND= <scene name='pdbligand=K:POTASSIUM+ION'>K</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jg5 OCA], [http://www.ebi.ac.uk/pdbsum/1jg5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jg5 RCSB]</span> | ||
}} | }} | ||
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[[Category: Ploom, T.]] | [[Category: Ploom, T.]] | ||
[[Category: Schiffmann, S.]] | [[Category: Schiffmann, S.]] | ||
| - | [[Category: K]] | ||
[[Category: alpha/beta structure]] | [[Category: alpha/beta structure]] | ||
[[Category: beta sheet]] | [[Category: beta sheet]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:33:15 2008'' |
Revision as of 18:33, 30 March 2008
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| , resolution 2.6Å | |||||||
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| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF RAT GTP CYCLOHYDROLASE I FEEDBACK REGULATORY PROTEIN, GFRP
Overview
Tetrahydrobiopterin, the cofactor required for hydroxylation of aromatic amino acids regulates its own synthesis in mammals through feedback inhibition of GTP cyclohydrolase I. This mechanism is mediated by a regulatory subunit called GTP cyclohydrolase I feedback regulatory protein (GFRP). The 2.6 A resolution crystal structure of rat GFRP shows that the protein forms a pentamer. This indicates a model for the interaction of mammalian GTP cyclohydrolase I with its regulator, GFRP. Kinetic investigations of human GTP cyclohydrolase I in complex with rat and human GFRP showed similar regulatory effects of both GFRP proteins.
About this Structure
1JG5 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, GFRP., Bader G, Schiffmann S, Herrmann A, Fischer M, Gutlich M, Auerbach G, Ploom T, Bacher A, Huber R, Lemm T, J Mol Biol. 2001 Oct 5;312(5):1051-7. PMID:11580249
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