2oq4
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oq4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oq4 RCSB], [http://www.ebi.ac.uk/pdbsum/2oq4 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oq4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oq4 RCSB], [http://www.ebi.ac.uk/pdbsum/2oq4 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/END8_ECOLI END8_ECOLI]] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Acts on DNA bubble and 3'-fork structures, suggesting a role in replication-associated DNA repair. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.<ref>PMID:20031487</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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*[[DNA glycosylase|DNA glycosylase]] | *[[DNA glycosylase|DNA glycosylase]] | ||
*[[Endonuclease|Endonuclease]] | *[[Endonuclease|Endonuclease]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: Golan, G | + | [[Category: Golan, G]] |
| - | [[Category: Grollman, A P | + | [[Category: Grollman, A P]] |
| - | [[Category: Shoahm, G | + | [[Category: Shoahm, G]] |
| - | [[Category: Zharkov, D O | + | [[Category: Zharkov, D O]] |
[[Category: Base excision]] | [[Category: Base excision]] | ||
[[Category: Covalent intermediate]] | [[Category: Covalent intermediate]] | ||
Revision as of 05:59, 25 December 2014
Crystal structure of the DNA repair enzyme endonuclease-VIII (Nei) from E. coli (E2Q) in complex with AP-site containing DNA substrate
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