1ji7
From Proteopedia
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|PDB= 1ji7 |SIZE=350|CAPTION= <scene name='initialview01'>1ji7</scene>, resolution 1.45Å | |PDB= 1ji7 |SIZE=350|CAPTION= <scene name='initialview01'>1ji7</scene>, resolution 1.45Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | + | |LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= TEL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= TEL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1bqv|1BQV]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ji7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ji7 OCA], [http://www.ebi.ac.uk/pdbsum/1ji7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ji7 RCSB]</span> | ||
}} | }} | ||
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==Disease== | ==Disease== | ||
| - | Known | + | Known disease associated with this structure: Leukemia, acute myeloid, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600618 600618]] |
==About this Structure== | ==About this Structure== | ||
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[[Category: Robinson, M A.]] | [[Category: Robinson, M A.]] | ||
[[Category: Tran, H H.]] | [[Category: Tran, H H.]] | ||
| - | [[Category: SO4]] | ||
[[Category: helical polymer]] | [[Category: helical polymer]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:34:01 2008'' |
Revision as of 18:34, 30 March 2008
| |||||||
| , resolution 1.45Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | TEL (Homo sapiens) | ||||||
| Related: | 1BQV
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of TEL SAM Polymer
Contents |
Overview
TEL is a transcriptional repressor that is a frequent target of chromosomal translocations in a large number of hematalogical malignancies. These rearrangements fuse a potent oligomerization module, the SAM domain of TEL, to a variety of tyrosine kinases or transcriptional regulatory proteins. The self-associating property of TEL-SAM is essential for cell transformation in many, if not all of these diseases. Here we show that the TEL-SAM domain forms a helical, head-to-tail polymeric structure held together by strong intermolecular contacts, providing the first clear demonstration that SAM domains can polymerize. Our results also suggest a mechanism by which SAM domains could mediate the spreading of transcriptional repression complexes along the chromosome.
Disease
Known disease associated with this structure: Leukemia, acute myeloid, somatic OMIM:[600618]
About this Structure
1JI7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression., Kim CA, Phillips ML, Kim W, Gingery M, Tran HH, Robinson MA, Faham S, Bowie JU, EMBO J. 2001 Aug 1;20(15):4173-82. PMID:11483520
Page seeded by OCA on Sun Mar 30 21:34:01 2008
