3c99
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c99 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3c99 RCSB], [http://www.ebi.ac.uk/pdbsum/3c99 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c99 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3c99 RCSB], [http://www.ebi.ac.uk/pdbsum/3c99 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CAF1_DROME CAF1_DROME]] Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the nucleosome remodeling and deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the nucleosome remodeling factor (NURF) complex, which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin; and the polycomb group (PcG) repressor complex ESC-E(Z), which promotes repression of homeotic genes during development. Also required for transcriptional repression of E2F target genes by E2f2 and Rbf or Rbf2.<ref>PMID:8887645</ref> <ref>PMID:9419341</ref> <ref>PMID:9784495</ref> <ref>PMID:12490953</ref> <ref>PMID:15456884</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
| - | [[Category: Garlick, J D | + | [[Category: Garlick, J D]] |
| - | [[Category: Kingston, R E | + | [[Category: Kingston, R E]] |
| - | [[Category: Song, J J | + | [[Category: Song, J J]] |
[[Category: Chromatin]] | [[Category: Chromatin]] | ||
[[Category: Chromatin regulator]] | [[Category: Chromatin regulator]] | ||
Revision as of 12:39, 25 December 2014
Structural Basis of Histone H4 Recognition by p55
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