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2par
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2par FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2par OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2par RCSB], [http://www.ebi.ac.uk/pdbsum/2par PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2par FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2par OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2par RCSB], [http://www.ebi.ac.uk/pdbsum/2par PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/YFBR_ECOLI YFBR_ECOLI]] Essential component of the deoxycytidine triphosphate (dCTP) pathway for de novo synthesis of thymidylate. Catalyzes the strictly specific dephosphorylation of 2'-deoxyribonucleoside 5'-monophosphates (dAMP, dGMP, dTMP, dUMP, dIMP and dCMP) and does not dephosphorylate 5'-ribonucleotides or ribonucleoside 3'-monophosphates.<ref>PMID:15489502</ref> <ref>PMID:17827303</ref> <ref>PMID:18353368</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: 5'-nucleotidase]] | [[Category: 5'-nucleotidase]] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: Minor, W | + | [[Category: Minor, W]] |
| - | [[Category: Proudfoot, M | + | [[Category: Proudfoot, M]] |
| - | [[Category: Yakunin, A | + | [[Category: Yakunin, A]] |
| - | [[Category: Zimmerman, M D | + | [[Category: Zimmerman, M D]] |
[[Category: 5'-deoxynucleotidase]] | [[Category: 5'-deoxynucleotidase]] | ||
[[Category: Hd domain phosphohydrolase]] | [[Category: Hd domain phosphohydrolase]] | ||
Revision as of 21:42, 24 December 2014
Crystal structure of the 5'-deoxynucleotidase YfbR mutant E72A complexed with Co(2+) and TMP
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