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2oz2
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oz2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oz2 RCSB], [http://www.ebi.ac.uk/pdbsum/2oz2 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oz2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2oz2 RCSB], [http://www.ebi.ac.uk/pdbsum/2oz2 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CYSP_TRYCR CYSP_TRYCR]] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Cruzipain]] | [[Category: Cruzipain]] | ||
[[Category: Trypanosoma cruzi]] | [[Category: Trypanosoma cruzi]] | ||
| - | [[Category: Brinen, L | + | [[Category: Brinen, L]] |
| - | [[Category: Rickert, M | + | [[Category: Rickert, M]] |
[[Category: Covalent inhibitor]] | [[Category: Covalent inhibitor]] | ||
[[Category: Cysteine protease]] | [[Category: Cysteine protease]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Vinyl sulfoneamide derived]] | [[Category: Vinyl sulfoneamide derived]] | ||
Revision as of 01:34, 25 December 2014
Crystal structure analysis of cruzain bound to vinyl sulfone derived inhibitor (K11777)
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