2kiz
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kiz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kiz RCSB], [http://www.ebi.ac.uk/pdbsum/2kiz PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kiz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kiz RCSB], [http://www.ebi.ac.uk/pdbsum/2kiz PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RN111_HUMAN RN111_HUMAN]] Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin-protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. Associates with UBE2D2 as an E2 enzyme.<ref>PMID:14657019</ref> <ref>PMID:16601693</ref> <ref>PMID:17591695</ref> <ref>PMID:22411132</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| - | [[Category: Bentrop, D | + | [[Category: Bentrop, D]] |
| - | [[Category: Chasapis, C T | + | [[Category: Chasapis, C T]] |
| - | [[Category: Episkopou, V | + | [[Category: Episkopou, V]] |
| - | [[Category: Kandias, N G | + | [[Category: Kandias, N G]] |
| - | [[Category: Spyroulias, G A | + | [[Category: Spyroulias, G A]] |
[[Category: Arkadia]] | [[Category: Arkadia]] | ||
[[Category: E3 ligase]] | [[Category: E3 ligase]] | ||
Revision as of 02:44, 25 December 2014
Solution structure of Arkadia RING-H2 finger domain
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