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VP24
From Proteopedia
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<StructureSection load='4D9O' size='340' side='right' caption='VP24 from the Reston Ebola Virus' scene=''> | <StructureSection load='4D9O' size='340' side='right' caption='VP24 from the Reston Ebola Virus' scene=''> | ||
== Introduction == | == Introduction == | ||
| - | VP24 is a protein present in the | + | VP24 is a protein present in the Ebola and Marburg viruses, both of which are members of ''Filoviridae'' family. Presently there are five strains of ebola: Sudan, Reston, Zire, Bundibugyo, and Taï Forest, each with minor differences in VP24 sequences(3). The Marburg virus has only one strain. |
== Function == | == Function == | ||
'''Ebola''' | '''Ebola''' | ||
| - | In a normal immune response interferons (IFN) are produced to alert surrounding cells of the presence of a pathogen. This response activates STAT1, which increases production of immune fighting genes in cells, by phosphorylation. STAT1 is brought to the nucleus by karyopherin α proteins. Ebola protein VP24 binds to karyopherin α1, α5, and α6, making it unable to transport the P-STAT1 to the nucleus. As a result the immune response in cells is then greatly weakened. The Reston strain is | + | In a normal immune response interferons (IFN) are produced to alert surrounding cells of the presence of a pathogen. This response activates STAT1, which increases production of immune fighting genes in cells, by phosphorylation. STAT1 is brought to the nucleus by karyopherin α proteins. Ebola protein VP24 binds to karyopherin α1, α5, and α6, making it unable to transport the P-STAT1 to the nucleus. As a result the immune response in cells is then greatly weakened. The Reston strain is the only strain that is not dangerous to humans. |
'''Marburg''' | '''Marburg''' | ||
Revision as of 22:11, 13 October 2014
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