This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
VP24
From Proteopedia
(Difference between revisions)
m |
m |
||
| Line 8: | Line 8: | ||
In a normal immune response interferons (IFN) are produced to alert surrounding cells of the presence of a pathogen. This response activates STAT1, which increases production of immune fighting genes in cells, by phosphorylation. STAT1 is brought to the nucleus by karyopherin α proteins. Ebola protein VP24 binds to karyopherin α1, α5, and α6, making it unable to transport the P-STAT1 to the nucleus. As a result the immune response in cells is then greatly weakened. The Reston strain is the only strain that is not dangerous to humans. | In a normal immune response interferons (IFN) are produced to alert surrounding cells of the presence of a pathogen. This response activates STAT1, which increases production of immune fighting genes in cells, by phosphorylation. STAT1 is brought to the nucleus by karyopherin α proteins. Ebola protein VP24 binds to karyopherin α1, α5, and α6, making it unable to transport the P-STAT1 to the nucleus. As a result the immune response in cells is then greatly weakened. The Reston strain is the only strain that is not dangerous to humans. | ||
| + | |||
| + | VP24 also is important for the structure of the virus. The structure of the nucleocapsid helix of Ebola | ||
'''Marburg''' | '''Marburg''' | ||
| Line 14: | Line 16: | ||
== Structural Characteristics == | == Structural Characteristics == | ||
| - | The | + | The Ebola and Marburg VP24 proteins are 30% identical. They share a similar pyramidal shape, as well as a few structures. Both viruses have two highly conserved pockets underneath the "pyramid's" base. Additionally, the N termini of Ebola (Zaire) and the Marburg virus are very similar. |
<scene name='60/602719/Reston_vp24/1'>Ebola Structure</scene> (Reston) | <scene name='60/602719/Reston_vp24/1'>Ebola Structure</scene> (Reston) | ||
Revision as of 22:19, 13 October 2014
VP24
| |||||||||||
