VP24
From Proteopedia
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== Function == | == Function == | ||
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'''Ebola''' | '''Ebola''' | ||
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<scene name='60/602719/Chain_b/1'>Ebola Domain</scene> (Reston) | <scene name='60/602719/Chain_b/1'>Ebola Domain</scene> (Reston) | ||
| - | There are a few structural characteristics only found in the Ebola viruses. At the top of the pyramidal domain, there are α helices present which are thought to interact with the α karyopherin. An α helix formed by the N-terminus runs from the top of the "pyramid" to one of the pockets located underneath the "pyramid." | + | There are a few structural characteristics only found in the Ebola viruses. At the top of the pyramidal domain, there are α helices present which are thought to interact with the α karyopherin. An α helix formed by the N-terminus runs from the top of the "pyramid" to another nearby VP24, where it binds to one of the pockets located underneath the "pyramid." |
<scene name='60/602719/Marburg_vp24_domain/1'>Marburg Structure</scene> | <scene name='60/602719/Marburg_vp24_domain/1'>Marburg Structure</scene> | ||
| - | + | Unlike the Ebola domain, the Marburg domain has two beta strands????? present that stick out quite far from the structure. Another difference is that the Marburg VP24 doesn't use an alpha helix to bind to another VP24, but rather a flexible strand that binds to a groove instead of a pocket. | |
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== α Karyopherin Binding == | == α Karyopherin Binding == | ||
Revision as of 23:37, 13 October 2014
VP24
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