Sandbox ceg1p Steven Paris

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 5: Line 5:
== Function of Ceg1p and the Cet1-Ceg1 mRNA Capping Complex ==
== Function of Ceg1p and the Cet1-Ceg1 mRNA Capping Complex ==
-
Ceg1p is an mRNA guanylyltransferase in ''Saccharomyces cerevisiae'' that forms a heterotetramer with the RNA triphosphatase cet1p and performs the first two steps in the 5’ guanine capping of mRNA (1).
+
Ceg1p is an mRNA guanylyltransferase in ''Saccharomyces cerevisiae'' that forms a heterotetramer with the RNA triphosphatase cet1p which is called the mRNA capping apparatus. This complex is recruited by RNA polymerase II (RNAP-II) and performs the first two steps in the 5’-guanisine capping mechanism of mRNA. Cet1p hydrolyzes the 5’-triphosphate end of the mRNA, then Ceg1p attaches a guanine monophosphate (GMP) to the 5’-diphosphate end (1).
== Disease ==
== Disease ==

Revision as of 00:31, 14 October 2014

Ceg1p mRNA Guanylyltransferase

cet1-ceg1 mRNA Capping Complex 3kyh

Drag the structure with the mouse to rotate

References

  1. Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
Personal tools