1jnq
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 1jnq |SIZE=350|CAPTION= <scene name='initialview01'>1jnq</scene>, resolution 2.1Å | |PDB= 1jnq |SIZE=350|CAPTION= <scene name='initialview01'>1jnq</scene>, resolution 2.1Å | ||
|SITE= <scene name='pdbsite=FE:Fe+(Fe+2)+Active+Site'>FE</scene> | |SITE= <scene name='pdbsite=FE:Fe+(Fe+2)+Active+Site'>FE</scene> | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=EGT:2-(3,4,5-TRIHYDROXY-PHENYL)-CHROMAN-3,5,7-TRIOL'>EGT</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Lipoxygenase Lipoxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.12 1.13.11.12] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Lipoxygenase Lipoxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.12 1.13.11.12] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1byt|1BYT]], [[1lnh|1LNH]], [[1f8n|1F8N]], [[1lox|1LOX]], [[1ik3|1IK3]], [[1hu9|1HU9]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jnq OCA], [http://www.ebi.ac.uk/pdbsum/1jnq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jnq RCSB]</span> | ||
}} | }} | ||
| Line 26: | Line 29: | ||
[[Category: Skrzypczak-Jankun, E.]] | [[Category: Skrzypczak-Jankun, E.]] | ||
[[Category: Zhou, K.]] | [[Category: Zhou, K.]] | ||
| - | [[Category: EGT]] | ||
| - | [[Category: FE2]] | ||
[[Category: catechin inhibitor]] | [[Category: catechin inhibitor]] | ||
[[Category: fe(ii) complex]] | [[Category: fe(ii) complex]] | ||
| Line 34: | Line 35: | ||
[[Category: purple lipoxygenase]] | [[Category: purple lipoxygenase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:36:20 2008'' |
Revision as of 18:36, 30 March 2008
| |||||||
| , resolution 2.1Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | , | ||||||
| Activity: | Lipoxygenase, with EC number 1.13.11.12 | ||||||
| Related: | 1BYT, 1LNH, 1F8N, 1LOX, 1IK3, 1HU9
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH EPIGALLOCATHECHIN (EGC)
Overview
Lipoxygenases (LOXs) are non-heme iron containing enzymes ubiquitous in nature and participating in the metabolism of the polyunsaturated fatty acids (PUFA). They are capable of combining their dioxygenase activity with its co-oxidative activity manifesting itself in biotransformation reactions catalyzed by LOXs for other than PUFA small molecules. LOXs involvement in inflammatory diseases and cancer have been well documented. Catechins are the natural flavonoids of known inhibitory activity toward dioxygenases with a potential to be utilized in disease prevention and treatment. This work presents results obtained from an X-ray analysis of (-)-epigallocatechin gallate (EGCG) interacting with soybean lipoxygenase-3. The 3D structure of the resulting complex reveals the inhibitor depicting (-)-epigallo-catechin that lacks galloyl moiety. The A-ring is near the iron co-factor, attached by the hydrogen bond to the C-terminus of the enzyme, and the B-ring hydroxyl groups participate in the hydrogen bonds and the van der Waals interactions formed by the surrounding amino acids and water molecules.
About this Structure
1JNQ is a Single protein structure of sequence from Glycine max. Full crystallographic information is available from OCA.
Reference
Inhibition of lipoxygenase by (-)-epigallocatechin gallate: X-ray analysis at 2.1 A reveals degradation of EGCG and shows soybean LOX-3 complex with EGC instead., Skrzypczak-Jankun E, Zhou K, Jankun J, Int J Mol Med. 2003 Oct;12(4):415-20. PMID:12964012
Page seeded by OCA on Sun Mar 30 21:36:20 2008
