4pla
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pla OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pla RCSB], [http://www.ebi.ac.uk/pdbsum/4pla PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pla OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pla RCSB], [http://www.ebi.ac.uk/pdbsum/4pla PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/P4K2A_HUMAN P4K2A_HUMAN]] Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells (By similarity). This lipid kinase is the major phosphatidylinositol 4-phosphate (PI4P) producer in the Golgi apparatus, it generates more than 50% of this molecule which is essential for the identity of the organelle, protein sorting and membrane trafficking. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Baumlova, A | + | [[Category: Baumlova, A]] |
| - | [[Category: Boura, E | + | [[Category: Boura, E]] |
| - | [[Category: Chalupska, D | + | [[Category: Chalupska, D]] |
[[Category: 4-kinase]] | [[Category: 4-kinase]] | ||
[[Category: Atp]] | [[Category: Atp]] | ||
Revision as of 01:14, 25 December 2014
Crystal structure of phosphatidyl inositol 4-kinase II alpha in complex with ATP
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Categories: Baumlova, A | Boura, E | Chalupska, D | 4-kinase | Atp | Hydrolase | Lipid | Phosphatidyl inositol | Transferase
