4qqe
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qqe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qqe RCSB], [http://www.ebi.ac.uk/pdbsum/4qqe PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qqe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qqe RCSB], [http://www.ebi.ac.uk/pdbsum/4qqe PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Al-Awar, R | + | [[Category: Al-Awar, R]] |
| - | [[Category: Arrowsmith, C H | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Bountra, C | + | [[Category: Bountra, C]] |
| - | [[Category: Brown, P J | + | [[Category: Brown, P J]] |
| - | [[Category: Dombrovski, L | + | [[Category: Dombrovski, L]] |
| - | [[Category: Dong, A | + | [[Category: Dong, A]] |
| - | [[Category: Edwards, A M | + | [[Category: Edwards, A M]] |
| - | [[Category: Getlik, M | + | [[Category: Getlik, M]] |
| - | [[Category: Poda, G | + | [[Category: Poda, G]] |
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[[Category: Structural genomic]] | [[Category: Structural genomic]] | ||
| - | [[Category: | + | [[Category: Schapira, M]] |
| + | [[Category: Senisterra, G]] | ||
| + | [[Category: Smil, D]] | ||
| + | [[Category: Vedadi, M]] | ||
| + | [[Category: Wernimont, A]] | ||
| + | [[Category: Wu, H]] | ||
| + | [[Category: Sgc]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
[[Category: Wdr5]] | [[Category: Wdr5]] | ||
Revision as of 12:52, 25 December 2014
Crystal structure of WDR5, WD repeat domain 5 in complex with compound SGC-DS-MT-0345
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Categories: Al-Awar, R | Arrowsmith, C H | Bountra, C | Brown, P J | Dombrovski, L | Dong, A | Edwards, A M | Getlik, M | Poda, G | Structural genomic | Schapira, M | Senisterra, G | Smil, D | Vedadi, M | Wernimont, A | Wu, H | Sgc | Transcription | Wdr5
