4pz3
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pz3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pz3 RCSB], [http://www.ebi.ac.uk/pdbsum/4pz3 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pz3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pz3 RCSB], [http://www.ebi.ac.uk/pdbsum/4pz3 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CD44_HUMAN CD44_HUMAN]] Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Finzel, B | + | [[Category: Finzel, B]] |
| - | [[Category: Liu, L K | + | [[Category: Liu, L K]] |
[[Category: Binding protein]] | [[Category: Binding protein]] | ||
[[Category: Cell adhesion]] | [[Category: Cell adhesion]] | ||
Revision as of 20:03, 25 December 2014
High-resolution crystal structure of the human CD44 hyaluronan binding domain complex with undefined peptides
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