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4pdz
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pdz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pdz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pdz RCSB], [http://www.ebi.ac.uk/pdbsum/4pdz PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pdz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pdz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pdz RCSB], [http://www.ebi.ac.uk/pdbsum/4pdz PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/S100B_BOVIN S100B_BOVIN]] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (By similarity).<ref>PMID:14661952</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Cavalier, M C | + | [[Category: Cavalier, M C]] |
| - | [[Category: Neau, D | + | [[Category: Neau, D]] |
| - | [[Category: Pierce, A D | + | [[Category: Pierce, A D]] |
| - | [[Category: Toth, E A | + | [[Category: Toth, E A]] |
| - | [[Category: Weber, D J | + | [[Category: Weber, D J]] |
| - | [[Category: Wilder, P T | + | [[Category: Wilder, P T]] |
[[Category: Calcium binding]] | [[Category: Calcium binding]] | ||
[[Category: Complex]] | [[Category: Complex]] | ||
Revision as of 06:28, 25 December 2014
Crystal Structure of Calcium-loaded S100B bound to SBi4172
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