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4tuh
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tuh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tuh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tuh RCSB], [http://www.ebi.ac.uk/pdbsum/4tuh PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tuh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tuh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tuh RCSB], [http://www.ebi.ac.uk/pdbsum/4tuh PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Colman, P M | + | [[Category: Colman, P M]] |
| - | [[Category: Czabotar, P E | + | [[Category: Czabotar, P E]] |
| - | [[Category: Lessense, G | + | [[Category: Lessense, G]] |
| - | [[Category: Smith, B J | + | [[Category: Smith, B J]] |
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
[[Category: Drug design]] | [[Category: Drug design]] | ||
Revision as of 01:23, 25 December 2014
Bcl-xL in complex with inhibitor (Compound 10)
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