4npn
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4npn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4npn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4npn RCSB], [http://www.ebi.ac.uk/pdbsum/4npn PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4npn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4npn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4npn RCSB], [http://www.ebi.ac.uk/pdbsum/4npn PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SUMO2_HUMAN SUMO2_HUMAN]] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.<ref>PMID:9556629</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Chen, C L | + | [[Category: Chen, C L]] |
| - | [[Category: Huang, T H | + | [[Category: Huang, T H]] |
| - | [[Category: Kung, C C.H | + | [[Category: Kung, C C.H]] |
| - | [[Category: Ma, C | + | [[Category: Ma, C]] |
| - | [[Category: Naik, M T | + | [[Category: Naik, M T]] |
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
[[Category: Protein transport]] | [[Category: Protein transport]] | ||
Revision as of 16:53, 25 December 2014
Crystal structure of human tetra-SUMO-2
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